Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Death receptor (DR) ligation elicits two different modes of cell death (necroptosis and apoptosis) depending on the cellular context. By screening a plant extract library from cells undergoing necroptosis or apoptosis, we identified a water extract of Terminalia chebula (WETC) as a novel and potent dual inhibitor of DR-mediated cell death. Investigation of the underlying mechanisms of its anti-necroptotic and anti-apoptotic action revealed that WETC or its constituents (e.g., gallic acid) protected against tumor necrosis factor-induced necroptosis via the suppression of TNF-induced ROS without affecting the upstream signaling events. Surprisingly, WETC also provided protection against DR-mediated apoptosis by inhibition of the caspase cascade. Furthermore, it activated the autophagy pathway via suppression of mTOR. Of the WETC constituents, punicalagi...

ISS Store: Kliebenstein Guides to Making Money in Self-Storage

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726. Though there are many nuances to running a self-storage operation, the key to profitability is to maximize revenue, decrease expenses and create property value. This is the central focus of How to Make Money in Self-Storage and How to Make MORE Money in Self-Storage, authored by RK Kliebenstein and Jennifer LeClaire. 100% Natural Vitamin E Price The first book in the series offers concrete, actionable strategies and programs facility operators can use to boost their bottom line. It includes sections on how to generate more income and manage expenses. The sequel offers additional guidance on revenue management and adds insight to equity generation. Kliebenstein, vice president of acquisitions for Metro Storage LLC, is an industry pioneer with more than 30 years of experience financing, developing, acquiring and managing self-storage properties. LeClaire is president and creative director of marketing firm Self Storage Promotions. The books are availabl...